BIOGRAPHICAL SKETCH

 

 

NAME

OZGUR KUTUK

 

POSITION TITLE

Assistant Professor

 

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

Sabanci University

Ph.D.

2006

Biological Sciences

Marmara University School of Medicine

M.D.

2000

Medicine

 

 

 

 

 

 

 

 

 

 

 

 

         

 

A. Positions and Honors.

 

Positions and Employment

 

  1.                 Research Assistant, Biological Sciences, Sabanci University, Istanbul, Turkey

2004-2005                  Visiting Scientist, Karolinska Institute, Cancer Centre Karolinska, Sweden

2006-2013                   Post-doctoral Research Fellow, Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

2015-                    Assistant Professor, Dept. of Medical Genetics, Baskent University School of Medicine, Ankara, Turkey

2018-                           Associate Professor, Dept. of Medical Genetics, Baskent University School of Medicine, Ankara, Turkey

 

Other Experience and Professional Memberships

 

2003-present        Member, European Association for Cancer Research

2007-present        Member, American Association for Cancer Research

2005-present        Member, European Cell Death Organization

2011-present        Member, American Society for Cell Biology

 

Honors

 

2001    FEBS (Federation of European Biochemical Societies) Summer Research Fellowship

2004    FEBS (Federation of European Biochemical Societies) Short Term Research Fellowship

2004    EACR (European Association for Cancer Research) Research Scholarship

2005    Terry Fox Cancer Research Grant

2009    Terri Brodeur Breast Cancer Foundation Postdoctoral Research Fellowship

2014    FEBS/EMBO Scholarship

2015    The Science Academy Young Scientist Award (BAGEP)

2016    MOKAD Young Cancer Investigator Award

 

 

B. Selected peer-reviewed publications (in chronological order).

 

Peer-reviewed papers:

 

  1. Kutuk O, Basaga H.  Aspirin prevents apoptosis and NF-kB activation induced by H2O2 in HeLa cells. Free Radic Res., 37: 1267-1276, 2003.

 

  1. Kutuk O, Basaga H. Inflammation meets oxidation: NF-kB as a mediator of initial lesion development in atherosclerosis. Trends Mol Med., 9: 549-557, 2003.

 

  1. Kutuk O, Basaga H.  Aspirin inhibits TNFa- and IL-1-induced NF-kB activation and sensitizes HeLa cells to apoptosis. Cytokine, 25:  229-237, 2004.

 

  1. Kutuk O, Adli M, Poli G, Basaga H. Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts. Biofactors, 20: 1-10, 2004.

 

  1. Kutuk O, Pedrech A, Harrison P, Basaga H. Pramanicin induces apoptosis in Jurkat leukemia cells: a role for JNK, p38 and caspase activation. Apoptosis, 10: 597-609, 2005.

 

  1. Kutuk O, Poli G, Basaga H.  Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling. Toxicol Sci., 90: 120-132, 2006.

 

  1. Kutuk O, Basaga H.  Bcl-2 protein family: implications in vascular apoptosis and atherosclerosis. Apoptosis, 11: 1661-1675, 2006.

 

  1. Arslan, MA, Kutuk O, Basaga H.  Protein Kinases as Drug Targets in Cancer. Curr Cancer Drug Targets, 6: 623-634, 2006.

 

  1.  Kutuk O, Basaga H.  Apoptosis signalling by 4-hydroxynonenal: a role for JNK-c-Jun/AP-1 pathway. Redox Rep., 12:30-34, 2007.

 

  1.  Gul O, Basaga H, Kutuk O. Apoptotic blocks and chemotherapy resistance: strategies to identify Bcl-2 protein signatures. Brief Funct Genomic Proteomic., 7:27-34, 2008.

 

  1.  Kutuk O, Letai A.  Regulation of Bcl-2 family proteins by posttranslational modifications. Curr Mol Med., 8:102-118, 2008.

 

  1.  Kutuk O, Letai A.  Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737. Cancer Res., 68:7985-7994, 2008.

 

  1.  Hernlund E, Kutuk O, Basaga H, Linder S, Panaretakis T, Shoshan M. Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation. Free Radic Biol Med., 46:1607-1613, 2009.

 

  1.  Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H. Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation. Carcinogenesis, 30:1517-1527, 2009.

 

  1.  Arisan ED, Kutuk O, Tezil T, Bodur C, Telci D, Basaga H. Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. Breast Cancer Res Treat., 119:271-281, 2010.

 

  1.  Kutuk O, Letai A. Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells. Cell Death Differ., 17:1624-1635, 2010.

 

  1.  Kutuk O, Temel SG, Tolunay S, Basaga H. Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL. Eur J Cancer, 46:2494-2505, 2010.

 

  1.  Tezil T, Bodur C, Kutuk O, Basaga H. IKK-β mediates chemoresistance by sequestering FOXO3; A critical factor for cell survival and death. Cell Signal., 24:1361-1368, 2012.

 

  1.  Bodur C, Kutuk O, Tezil T, Basaga H. Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE).  J Cell Physiol., 227: 3556-3565, 2012.

 

  1.  Timucin C, Gul O, Kutuk O, Basaga H. Antibody array-based immunosensor for detecting cardiovascular disease risk markers. J Immunoassay Immunochem., 33:275-290, 2012.

 

  1. Bodur C, Kutuk O, Karsli-Uzunbas G, Isimjan TT, Harrison P, Basaga H. Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling. PLoS One, 8:e56369, 2013.

 

  1. Kutuk O, Aytan N, Karakas B, Kurt AG, Acikbas U, Temel SG, Basaga H. Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells. PLoS One, 12:e0182809, 2017.

 

  1. Kutuk MO, Guler G, Tufan AE, Kutuk O. Hiccup Due to Aripiprazole Plus Methylphenidate Treatment in an Adolescent with Attention Deficit and Hyperactivity Disorder and Conduct Disorder: A Case Report. Clin Psychopharmacol Neurosci., 15:410-412, 2017.

 

  1. Acikbas U, Kutuk MO, Tufan AE, Kutuk O, Seddigh SH, Mahboobi H. Effects of childhood cancer on family life and child with cancer. J Med Res Healthc., 2:122-133, 2017.

 

  1. Kutuk MO, Altintas E, Tufan AE, Guler G, Aslan B, Aytan N, Kutuk O. Developmental delays and psychiatric diagnoses are elevated in offspring staying in prisons with their mothers. Sci Rep., 8: 1856, 2018. doi: 10.1038/s41598-018-20263-x

 

  1. Saatci Ö, Borgoni S, Akbulut Ö, Durmuş S, Raza U, Eyüpoğlu E, Alkan C, Akyol A, Kütük Ö, Wiemann S, Şahin Ö. Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer. Oncogene. 2018 Feb 2. doi: 10.1038/s41388-017-0108-9

 

  1. Karakas B, Ozmay Y, Basaga H, Gul O, Kutuk O. Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+ breast cancer cells. Biochim Biophys Acta., 1865:1073-1087, 2018. https://doi.org/10.1016/j.bbamcr.2018.05.002

 

  1. Timucin AC, Basaga H, Kutuk O. Selective targeting of antiapoptotic BCL-2 proteins in cancer. Med Res Rev. 2018 May 30. doi: 10.1002/med.21516. [Epub ahead of print]

 

  1. Kilic-Kurt Z, Bakar-Ates F, Karakas B, Kutuk O.  Cytotoxic and apoptotic effects of novel pyrrolo[2,3-d]pyrimidine derivatives containing urea moieties on cancer cell lines. Anticancer Agents Med Chem. 2018 Jun 4. doi: 10.2174/1871520618666180605082026. [Epub ahead of print]

 

  1. Kale J, Kutuk O, Brito GC, Andrews TS, Leber B, Letai A, Andrews DW.  Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. EMBO Rep., in press.

Proceedings:

 

  1. Kutuk O and Basaga H. Modulation of H2O2 and TNF-alpha induced NF-KB activation by acetylsalicylic acid (Aspirin). (Proceedings of 11th Biannual Meeting of SFRR, Paris, France, July 16-22, 2002) Free Radic Biol Med., 33:S62-S62, 2002.

 

  1. Kutuk O, Poli G, Basaga H. The role of caspases, JNK and AP-1 in 4-HNE-induced apoptosis in 3T3 fibroblasts. (12th Biennial Meeting of the SFRR, Buenos Aires, Argentina, May 5-9, 2004)  Free Radic Biol Med., 36:S37-S38, 2004.

 

  1. Gul O, Inceturkmen E, Kutuk O, Basaga H, Sezerman U and Gurbuz Y. Biosensor Implementation for Cardiovascular Risk Marker Analysis, Vol. 1 and 2, 303-305, 4th IEEE Conference on Sensors, 2005.

 

  1. Kutuk O, Pedrech A, Harrison P, Basaga H. Pramanicin induces apoptosis in Jurkat leukemia cells: a role for JNK, p38 and caspase activation. (13th European Cancer Conference-ECCO 13, Paris, France, October 30-November 3, 2005) Eur J Cancer Suppl., 3:S50-S50, 2005.

 

  1. Arisan ED, Kutuk O, Verim A, Basaga H. Molecular mechanism of paclitaxel-induced apoptosis in ER+/- breast cancer cell lines: MCF-7 and MDA-MB-231. (31st Congress of the Federation of European Biochemical Societies (FEBS), Istanbul, Turkey, June 24-29, 2006) FEBS J, 273:S51-S52, 2006.

 

  1. Bodur C, Kutuk O, Poli G, Basaga H.: Role of Bcl-2 protein family members in 4-hydroxynonenal mediated apoptosis.  (Europe Meeting 2009 of SFRR, Rome, Italy, August 26-29, 2009) Free Radic Res., 43:34-34, 2009.

 

  1. Letai A, Kutuk O, Vo T, Ryan J, Deng J, Sarosiek K, Chonghaile TN. The mitochondrial basis of resistance to BCL-2 antagonists and conventional chemotherapy. (24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Ireland, November 6-9, 2012) Eur J Cancer, 48:133-133, 2012.

 

  1. Kutuk O. The coordinated action of BIK, p53 and ROS in DNA damage-induced cell death. (FEBS EMBO 2014 Conference, August 30-September 4, 2014) FEBS J, 281:S506-S506, 2014.

 

 

Book Chapters:

 

  1. Kutuk O, Basaga H. Phytoestrogens and cellular signalling, in Phytoestrogens in Functional Foods, Taylor&Francis, 123-152, 2005, Editor: Yildiz F.

 

  1. Kutuk O, Telci D, Basaga H. Lipid peroxidation, gene expression and resveratrol; implications in atherosclerosis, in Phytochemicals: Nutrient-gene interactions. CRC Press, 61-82, 2006, Eds. Meskin M, Bidlack W, Randolph K.

 

  1. Kutuk O, Basaga H. Apoptotic pathways in mitochondria, in Apoptosis: Modern insights into disease from molecules to man. Science Publishers/CRC Press, 3-18, 2010, Editor: Preedy VR. 2010.

 

C. Research Support.

 

Ongoing Research Projects

 

 

  1. TUBITAK-113S872 (Kutuk PI)                           01/04/2014-01/04/2017                

Title: “Exploring the effects of mitochondrial estrogen receptors on mitochondrial priming and endocrine therapy response in breast cancer cells.”

 

  1. TUBITAK-116S232 (Kutuk PI)                          15/01/2017-15/01/2018                 

Title: “

 

Completed Research Support

 

 

  1. TUBITAK-113S481 (Kutuk PI)                          15/11/2013-15/11/2014                 

Title: “Exploring the role of p53-BIK-ROS axis in DNA damage-induced cell death.”

 

  1. Terri Brodeur Breast Cancer Foundation Kutuk (PI)             01/01/2009-01/01/2011

Title: “Exploring and exploiting the mechanisms of paclitaxel-induced breast cancer cell death.”

Mentor: Letai

 

  1. RSG 07-143-01-CCG  Letai (PI)                                         07/01/07-06/30/08     

Sponsor: American Cancer Society

Title: “ A Novel Strategy for Defining BCL-2 Addiction in Cancer”

Role: Co-investigator

 

  1. Kimmel Scholar Award,   Letai (PI)                                       7/1/05-6/30/07          

Sponsor: Sidney Kimmel Foundation for Cancer Research

Title: “Targeting apoptotic defects in cancer.”

Role: Co-investigator

 

  1. TUBITAK-SBAG-2863  Basaga (PI)                                    2005-2006     

Protein microchip design for molecular diagnostics

Role: Co-investigator

 

  1. TKV (Turkish Association for Cancer Research and Control) (Kutuk PI)   2005-2006

Terry Fox Cancer Research Grant

Bcl-2 protein expression and chemotherapy resistance: investigating effect of siRNA-based Bcl-2 gene silencing on the sensitivity of breast cancer cells to apoptosis.

 

  1. TUBITAK-SBAG-2667 (Basaga PI)                                     2003-2005     

Cytokine induced gene expression and its role on signal transduction pathways and gene expression

Role: Co-investigator